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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPAN All Species: 12.12
Human Site: S456 Identified Species: 19.05
UniProt: Q9NQ55 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NQ55 NP_001035754.1 473 53194 S456 R R G P R G A S R D G G R G R
Chimpanzee Pan troglodytes XP_001150990 706 78742 E698 T A A P K Q S E P Q S H E L S
Rhesus Macaque Macaca mulatta XP_001100297 471 52923 S454 R R G P R G A S R D G G R G Q
Dog Lupus familis XP_533920 792 88144 T610 T E R P E A C T K C L G M A D
Cat Felis silvestris
Mouse Mus musculus Q91YU8 470 52707 H459 K P R P R A T H Q D S R P A S
Rat Rattus norvegicus NP_001011980 470 52521 S459 K L G P R A R S R D L G P P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519003 490 55177 S476 P R L W K R G S G P H G R T G
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_958871 522 59529 T454 K Q F G Y K K T L E G R S Q F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VDE5 460 53074 R448 K F D P K N K R A K F D H R K
Honey Bee Apis mellifera XP_395421 413 48031 K404 E I G E E P D K D L F E R K V
Nematode Worm Caenorhab. elegans NP_491108 573 63766 G537 G F G G R G G G G F R G G D R
Sea Urchin Strong. purpuratus XP_787585 300 34175 V293 E G L G E G E V L Y H E S S E
Poplar Tree Populus trichocarpa XP_002302711 297 33281 S290 C S G D V I F S E Y G M F I V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ASU7 345 38823 D338 G S E E D G E D M D E D F E D
Baker's Yeast Sacchar. cerevisiae P38789 453 51746 E442 E H Y G S V P E D L D S D L F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 64.1 95.7 48.8 N.A. 73.3 73.5 N.A. 62 N.A. N.A. 53 N.A. 35 38.9 31.4 36.3
Protein Similarity: 100 65.4 97.4 54 N.A. 81.6 81.8 N.A. 75.3 N.A. N.A. 70.1 N.A. 57.5 59.2 49.5 47.9
P-Site Identity: 100 6.6 93.3 13.3 N.A. 20 46.6 N.A. 26.6 N.A. N.A. 6.6 N.A. 6.6 13.3 33.3 6.6
P-Site Similarity: 100 20 100 26.6 N.A. 33.3 53.3 N.A. 33.3 N.A. N.A. 33.3 N.A. 26.6 13.3 33.3 6.6
Percent
Protein Identity: 28.7 N.A. N.A. 32.9 25.5 N.A.
Protein Similarity: 42.9 N.A. N.A. 50.5 44.8 N.A.
P-Site Identity: 20 N.A. N.A. 13.3 0 N.A.
P-Site Similarity: 20 N.A. N.A. 13.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 20 14 0 7 0 0 0 0 14 0 % A
% Cys: 7 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % C
% Asp: 0 0 7 7 7 0 7 7 14 34 7 14 7 7 14 % D
% Glu: 20 7 7 14 20 0 14 14 7 7 7 14 7 7 7 % E
% Phe: 0 14 7 0 0 0 7 0 0 7 14 0 14 0 14 % F
% Gly: 14 7 40 27 0 34 14 7 14 0 27 40 7 14 7 % G
% His: 0 7 0 0 0 0 0 7 0 0 14 7 7 0 0 % H
% Ile: 0 7 0 0 0 7 0 0 0 0 0 0 0 7 0 % I
% Lys: 27 0 0 0 20 7 14 7 7 7 0 0 0 7 7 % K
% Leu: 0 7 14 0 0 0 0 0 14 14 14 0 0 14 0 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 7 7 0 0 % M
% Asn: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 7 0 47 0 7 7 0 7 7 0 0 14 7 0 % P
% Gln: 0 7 0 0 0 7 0 0 7 7 0 0 0 7 7 % Q
% Arg: 14 20 14 0 34 7 7 7 20 0 7 14 27 7 14 % R
% Ser: 0 14 0 0 7 0 7 34 0 0 14 7 14 7 20 % S
% Thr: 14 0 0 0 0 0 7 14 0 0 0 0 0 7 0 % T
% Val: 0 0 0 0 7 7 0 7 0 0 0 0 0 0 14 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 7 0 0 0 0 14 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _